Rapid Multi-Attribute Monitoring of Complex Biologics
Post-translational modifications can change the isoelectric point of a monoclonal antibody (mAb), so characterizing the charge heterogeneity of mABs is important to ensure the safety, efficacy and potency of biologics.
Imaged capillary isoelectric focusing (icIEF) is commonly used to monitor charge variant profiles. However, numerous technical challenges inhibit the direct combination of icIEF-UV characterization with identification by mass spectrometry.
This webinar highlights a system that offers direct integration of icIEF with mass spectrometry to allow confident characterization of biotherapeutics and reliable quantitation of charge variants.
Watch this webinar to learn more about:
- Integrating icIEF-UV/MS in biologics discovery and development
- Applications of the microfluidic chip-based integrated icIEF-UV/MS workflow
- Streamlining pipeline development through comprehensive charge heterogeneity characterization
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