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Drug Targets

This page provides educational resources, events, news and products related to drug targets. Content will cover aspects from identification and validation of new drug targets, to therapeutic development and the benefits to health.

Drug Targets – Highlights

Visualizing Drug Targets With Ligand Express content piece image

Industry Insight

Visualizing Drug Targets With Ligand Express

In the development of a therapeutic pharmaceutical agent, it is crucial to understand the on- and off-target effects the molecule may have within the body. Cyclica's Ligand Express® is a cloud-based platform that screens small-molecule drugs against structurally-characterized proteins, or "proteomes" to determine polypharmacological profiles. We spoke with Naheed Kurji, President & CEO, and Andreas Windemuth, Chief Science Officer, from Cyclica to find out more.

Screening Strategies Used in Drug Discovery

This article highlights some of the different screening strategies used during drug discovery. Key advances and challenges associated with the techniques are also discussed.

The Changing Landscape of Target-Based Drug Discovery

In this article, we discuss the cost of developing a drug, what makes a good drug target, the challenges and benefits of target-based drug discovery and how target-based approaches compare to phenotypic led approaches.

Industry Insight

On Target: Next-Generation Proteomics Takes the Uncertainty Out of Drug Discovery

Multi-dimensional insights into the effects of drugs on protein structure and function can help de-risk the drug discovery process, building confidence in new drug candidates and their mechanism of action before moving on to the next more costly stage of development.

Drug–Target Binding: Recent Research Developments

Being able to accurately predict drug–target interactions (DTIs) and drug–target binding affinity (DTBA) is crucial in early drug development and during drug repurposing endeavors. Here, we look at some recent research developments in this space.

Drug Targets – News and Features

Molecular Glue Degraders Could Target “Undruggable” Proteins

Cells contain molecular machinery that targets and disposes of unwanted proteins. Scientists would like to hijack this process to control proteins involved in cancer and other diseases, using a type of molecule called a molecular glue degrader.

Drug Screen Identifies Compounds That May Combat Diabetes

A drug currently in clinical trials as a cancer therapy can also stimulate pancreatic beta cells to secrete insulin, revealing a previously unknown mechanism for insulin regulation in type 2 diabetes.

Cellular Atlas Built To Guide Precision Treatment of Rheumatoid Arthritis

Precision treatment for rheumatoid arthritis is key. New research has used a cellular atlas to outline the variety of cellular causes, which may inform targeted, effective therapies.

Promising Antibiotic Breakthrough Unveiled for Lyme Disease

Using a technique that has shown promise in targeting cancer tumors, a Duke Health team has found a way to deploy a molecular warhead that can annihilate the bacterium that causes Lyme disease.

Extracting Meaningful Data With High-Throughput Drug Discovery Approaches

This article focuses on the use of high-throughput screening approaches in drug discovery and discusses the latest developments in this area.

Breast Cancer Metastasis Discovery May Offer New Avenues for Treatment

A new study has revealed some of the mechanics underlying how breast cancer cells invade healthy tissues. The research, which may offer new drug targets against the spread of cancer cells (metastasis), is published in Advanced Science.

Drug Targets – Multimedia

Kinetic Analysis

Kinetic Analysis: Spotting the Weakest Binders

Target-Based Drug Discovery content piece image

Target-Based Drug Discovery

Revolutionary Binding Kinetics Analysis content piece image

Revolutionary Binding Kinetics Analysis

Drug Targets – Webinars and Online Events

TechNet Multiomics ed cal 12th december 2023

Innovations in Multiomics Research for Life Sciences

Somalogic

Using Plasma Proteomics To Understand Alzheimer’s and Other Brain Diseases

An Introduction to Grating-Coupled Interferometry (GCI) content piece image

An Introduction to Grating-Coupled Interferometry (GCI)

Related Products

Engaging in research is like participating in a high-stakes poker match.

Don't Gamble With Your Research: The Winning Hand of Label-Free Protein Characterization

App Note / Case Study

Determine Kinetics Earlier in the Drug Discovery Process

Bio-Rad Extends Range of Anti-Idiotypic Antibodies for Use in Preclinical and Clinical Drug Development

Sygnature Discovery Launches Its LPS In Vivo Model To Profile Early-Stage Anti-Inflammatory Drugs

App Note / Case Study

Assess Small Molecule Kinetics and Affinity in Just One Step

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